After several rounds of analysis—with the help of a specially developed machine-learning algorithm—the team identified five regions in the genome where the methylation pattern appears very closely linked to sexual orientation.
One gene is important for nerve conduction, whereas another has been implicated in immune functions. To test how important the five regions are, the team divided the discordant twin pairs into two groups. They looked at the associations between specific epi-marks and sexual orientation in one group, then tested how well those results could predict sexual orientation in the second group. Just why identical twins sometimes end up with different methylation patterns isn't clear.
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If Rice's hypothesis is right, their mothers' epi-marks might have been erased in one son, but not the other; or perhaps neither inherited any marks but one of them picked them up in the womb. In an earlier review, Ngun and Vilain cited evidence that methylation may be determined by subtle differences in the environment each fetus experiences during gestation, such as their exact locations within the womb and how much of the maternal blood supply each receives.
By Meredith Wadman Apr. By Jocelyn Kaiser Apr.
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The Ultimate Sexual Orientation Test: Straight, Gay, or in Between?
Science Insider. Prominent neuroscientist worked for months after university found he violated sexual relationship policies By Meredith Wadman Apr.
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